| 123.07 (48/39) | CH Gayle | West Indies v South Africa at Barbados, 3rd Test, 29/03/2001 [1541] |
| 66.45 (103/155) | DJ Cullinan | South Africa v West Indies at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 66.25 (53/80) | JH Kallis | South Africa v West Indies at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 60.82 (59/97) | MN Samuels | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 56.33 (40/71) | CH Gayle | West Indies v South Africa at Barbados, 3rd Test, 29/03/2001 [1541] |
| 55.31 (52/94) | MV Boucher | South Africa v West Indies at Georgetown, 1st Test, 09/03/2001 [1534] |
| 54.87 (45/82) | BC Lara | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 54.35 (106/195) | SM Pollock | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 53.84 (35/65) | CL Hooper | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 53.03 (35/66) | MN Samuels | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 52.55 (113/215) | RD Jacobs | West Indies v South Africa at Barbados, 3rd Test, 29/03/2001 [1541] |
| 52.54 (93/177) | RD Jacobs | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 51.92 (81/156) | BC Lara | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 50.94 (81/159) | CH Gayle | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 50.27 (91/181) | RR Sarwan | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 50.00 (74/148) | CL Hooper | West Indies v South Africa at Barbados, 3rd Test, 29/03/2001 [1541] |
| 49.26 (134/272) | DJ Cullinan | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 49.12 (56/114) | WW Hinds | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 48.71 (38/78) | MV Boucher | South Africa v West Indies at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 48.43 (31/64) | L Klusener | South Africa v West Indies at Jamaica, 5th Test, 19/04/2001 [1544] |
| 47.36 (72/152) | ND McKenzie | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 47.22 (34/72) | HH Gibbs | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 45.97 (40/87) | MN Samuels | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 45.72 (91/199) | BC Lara | West Indies v South Africa at Antigua, 4th Test, 06/04/2001 [1542] |
| 45.45 (45/99) | ND McKenzie | South Africa v West Indies at Jamaica, 5th Test, 19/04/2001 [1544] |
| 45.21 (85/188) | HH Gibbs | South Africa v West Indies at Antigua, 4th Test, 06/04/2001 [1542] |
| 44.87 (35/78) | ND McKenzie | South Africa v West Indies at Antigua, 4th Test, 06/04/2001 [1542] |
| 44.62 (83/186) | BC Lara | West Indies v South Africa at Barbados, 3rd Test, 29/03/2001 [1541] |
| 44.56 (41/92) | SM Pollock | South Africa v West Indies at Antigua, 4th Test, 06/04/2001 [1542] |
| 44.50 (85/191) | RD Jacobs | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 44.37 (150/338) | G Kirsten | South Africa v West Indies at Georgetown, 1st Test, 09/03/2001 [1534] |
| 44.33 (47/106) | BC Lara | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 44.23 (69/156) | CL Hooper | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 42.50 (51/120) | HH Gibbs | South Africa v West Indies at Jamaica, 5th Test, 19/04/2001 [1544] |
| 42.06 (53/126) | CL Hooper | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 41.23 (40/97) | SM Pollock | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 41.01 (73/178) | DJ Cullinan | South Africa v West Indies at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 40.69 (35/86) | D Ramnarine | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 40.00 (34/85) | HH Gibbs | South Africa v West Indies at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 39.53 (51/129) | JH Kallis | South Africa v West Indies at Jamaica, 5th Test, 19/04/2001 [1544] |
| 39.28 (44/112) | CH Gayle | West Indies v South Africa at Georgetown, 1st Test, 09/03/2001 [1534] |
| 38.60 (83/215) | HH Gibbs | South Africa v West Indies at Georgetown, 1st Test, 09/03/2001 [1534] |
| 37.77 (34/90) | RR Sarwan | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 36.00 (27/75) | LV Garrick | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 35.21 (25/71) | CL Hooper | West Indies v South Africa at Jamaica, 5th Test, 19/04/2001 [1544] |
| 34.45 (82/238) | DJ Cullinan | South Africa v West Indies at Barbados, 3rd Test, 29/03/2001 [1541] |
| 34.24 (25/73) | RR Sarwan | West Indies v South Africa at Antigua, 4th Test, 06/04/2001 [1542] |
| 34.21 (39/114) | RR Sarwan | West Indies v South Africa at Port of Spain, 2nd Test, 17/03/2001 [1538] |
| 34.11 (29/85) | WW Hinds | West Indies v South Africa at Antigua, 4th Test, 06/04/2001 [1542] |
| 33.33 (30/90) | JH Kallis | South Africa v West Indies at Georgetown, 1st Test, 09/03/2001 [1534] |