| 132 | CH Gayle | West Indies v South Africa at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 123 | HH Dippenaar | South Africa v West Indies at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 103 | GC Smith | South Africa v West Indies at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 89* | AG Prince | South Africa v West Indies at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 87 | JH Kallis | South Africa v West Indies at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 85* | S Chanderpaul | West Indies v South Africa at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 72 | RR Sarwan | West Indies v South Africa at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 65 | JM Kemp | South Africa v West Indies at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 61* | HH Dippenaar | South Africa v West Indies at Port of Spain, 5th ODI, 15/05/2005 [2245] |
| 60* | HH Dippenaar | South Africa v West Indies at Jamaica, 2nd ODI, 08/05/2005 [2242] |
| 56 | HH Dippenaar | South Africa v West Indies at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 51* | JH Kallis | South Africa v West Indies at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 49 | S Chanderpaul | West Indies v South Africa at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 48 | RR Sarwan | West Indies v South Africa at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 46* | CO Browne | West Indies v South Africa at Jamaica, 2nd ODI, 08/05/2005 [2242] |
| 46 | DR Smith | West Indies v South Africa at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 44* | HH Gibbs | South Africa v West Indies at Jamaica, 2nd ODI, 08/05/2005 [2242] |
| 41* | DJJ Bravo | West Indies v South Africa at Port of Spain, 5th ODI, 15/05/2005 [2245] |
| 40* | HH Gibbs | South Africa v West Indies at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 36 | S Chanderpaul | West Indies v South Africa at Jamaica, 2nd ODI, 08/05/2005 [2242] |
| 32 | BC Lara | West Indies v South Africa at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 30 | AB de Villiers | South Africa v West Indies at Port of Spain, 5th ODI, 15/05/2005 [2245] |
| 28 | GC Smith | South Africa v West Indies at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 28 | DJJ Bravo | West Indies v South Africa at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 28 | CH Gayle | West Indies v South Africa at Port of Spain, 5th ODI, 15/05/2005 [2245] |
| 26 | CH Gayle | West Indies v South Africa at Jamaica, 1st ODI, 07/05/2005 [2241] |
| 23 | S Chanderpaul | West Indies v South Africa at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 22 | BC Lara | West Indies v South Africa at Port of Spain, 4th ODI, 14/05/2005 [2244] |
| 21* | DJJ Bravo | West Indies v South Africa at Barbados, 3rd ODI, 11/05/2005 [2243] |
| 21 | DR Smith | West Indies v South Africa at Barbados, 3rd ODI, 11/05/2005 [2243] |
