| 217.64 (37/17) | Harbhajan Singh | India v South Africa at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 176.47 (30/17) | SM Pollock | South Africa v India at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 142.85 (30/21) | V Sehwag | India v South Africa at Kolkata, 4th ODI, 25/11/2005 [2299] |
| 135.00 (27/20) | V Sehwag | India v South Africa at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 133.33 (48/36) | GC Smith | South Africa v India at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 124.19 (77/62) | V Sehwag | India v South Africa at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 108.06 (134/124) | GC Smith | South Africa v India at Kolkata, 4th ODI, 25/11/2005 [2299] |
| 93.87 (46/49) | JM Kemp | South Africa v India at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 84.42 (103/122) | Yuvraj Singh | India v South Africa at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 76.56 (49/64) | Yuvraj Singh | India v South Africa at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 76.00 (38/50) | G Gambhir | India v South Africa at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 74.41 (32/43) | AJ Hall | South Africa v India at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 73.58 (78/106) | R Dravid | India v South Africa at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 73.01 (46/63) | IK Pathan | India v South Africa at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 73.01 (46/63) | M Kaif | India v South Africa at Kolkata, 4th ODI, 25/11/2005 [2299] |
| 70.10 (68/97) | JH Kallis | South Africa v India at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 68.18 (30/44) | SR Tendulkar | India v South Africa at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 67.94 (53/78) | Yuvraj Singh | India v South Africa at Kolkata, 4th ODI, 25/11/2005 [2299] |
| 63.79 (37/58) | IK Pathan | India v South Africa at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 62.50 (35/56) | MV Boucher | South Africa v India at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 62.32 (91/146) | JH Kallis | South Africa v India at Mumbai, 5th ODI, 28/11/2005 [2300] |
| 62.16 (46/74) | AG Prince | South Africa v India at Hyderabad, 1st ODI, 16/11/2005 [2297] |
| 51.06 (48/94) | AJ Hall | South Africa v India at Kolkata, 4th ODI, 25/11/2005 [2299] |
| 47.54 (29/61) | SM Pollock | South Africa v India at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 47.45 (28/59) | JM Kemp | South Africa v India at Bangalore, 2nd ODI, 19/11/2005 [2298] |
| 43.47 (30/69) | AG Prince | South Africa v India at Bangalore, 2nd ODI, 19/11/2005 [2298] |
